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Zyban is a medication prescribed to patients willing to quit smoking as a part of complex smoking cessation program. It is available in the form of tablets that are usually taken by the patient twice a day. Zyban works by blocking the reuptake of certain chemicals in the human brain tissue. The most common side effects of this medication include insomnia, the feeling of dryness in the mouth cavity and constipation.
What Is Zyban And What Is It Used for?
Zyban (generic name: bupropion SR) is a prescription drug used in the treatment of nicotine addiction.
Who Manufactures Zyban?
Currently, Zyban is made by GlaxoSmithKline pharmaceutical company.
What Is the Effect of Zyban Based Upon?
Zyban was primarily introduced and used as an antidepressant. Its main active component, bupropion, is included into several medications licensed for use in the treatment of depression, such as Wellbutrin, Wellbutrin SR, and Wellbutrin XR. Zyban belongs to a group of drugs known under the common name norepinephrine and dopamine reuptake inhibitors (also known as NDRIs). NDRIs affect certain chemicals (norepinephrine and dopamine) contained in the human brain tissue and used to transfer nerve signals among cells.
The process of reuptake can be shortly described in the following manner: a signal moving along the nerve causes a cell to release either norepinephrine or dopamine. After that, the chemical enters the empty space between a nerve cell and the one adjacent to it. When a sufficient amount of norepinephrine or dopamine reaches the following nerve cell, the process of transferring the signal is continued. Meanwhile, the first nerve cell absorbs the norepinephrine or dopamine occupying the space between cells.
Zyban blocks the absorption of norepinephrine and dopamine by the nerve cells following the transmission of the nerve signal, thus making the process of activating the receptors in adjacent cells much easier. This process is widely believed to be affecting the people willing to quit smoking in a positive way.
Studies of the Effects of Zyban
There have been a number of successful clinical researches showing that Zyban can help people quit smoking when it's used as a part of smoking cessation therapy. Up to 36% of people taking this medication were able to quit smoking during the therapy while the same showing in the group of patients not using Zyban was as low as 17%. The use of Zyban in combination with nicotine patches showed even better results – as much as 58% of people taking part in the studies managed to quit smoking during the course of treatment.
The results of the researches carried out also show that the use of Zyban can fight such nicotine withdrawal symptoms as:
- Increased irritability
- The feeling of frustration
- Anger
- Anxiety
- Concentration disorders
- Restlessness
- Depression.
Moreover, the studies have revealed that the people continuing the therapy with Zyban after quitting smoking are significantly less likely to start smoking again in the future.
How Do I Take Zyban?
Here are some general recommendations considering the use of Zyban:
- It's necessary to start taking Zyban at least one week before you try to quit smoking since some time is required for a sufficient amount of the active component to build up in your system.
- Zyban is available in the form of tablets intended for peroral administration. In most cases, you will be prescribed to take Zyban twice each day.
- Zyban tablets are to be swallowed whole. Never cut, crush, chew or break your Zyban tablets.
- Zyban can be taken both with and without food. However, if this medication causes upset stomach, try taking it in the course of a meal.
- It's important to maintain an even level of the active component in your blood flow, so it would be better if you take Zyban at the same time each day.
- Never stop the therapy with Zyban unless instructed to do so by your healthcare provider. The medicine will stop working if you quit taking it.
Zyban Dosage
The factors that can lead to the adjustment of dosage for a particular patient are the following:
- The age of the patient
- The presence or absence of other specific medical conditions
- Simultaneous therapy with other medications.
We strongly recommend you not to try adjusting your dosage of Zyban by yourself without getting special instructions from your therapist.
Possible Side Effects of Therapy with Zyban
Zyban is known to cause certain side effects – both minor and severe ones. However, most of the people on Zyban are not likely to suffer from any of its side effects. Most of the reported side effects either require no special treatment or can easily be treated by your healthcare provider or yourself.
The short list of most common side effects of Zyban includes the following:
- Loss of sleep
- Feeling of dryness in the mouth cavity
- Problems with concentration
- Constipation
- Dizziness.
Possible Drug Interactions with Zyban
The short list of drugs and substances that Zyban can possibly interact with includes:
- Alcohol
- Other antidepressants
- Amantadine
- Certain antipsychotic medications
- Beta blockers
- Certain medications used in the treatment of heart arrhythmia
- Cyclophosphamide
- Doxorubicin
- Efavirenz
- Levodopa
- Certain MAOIs (monoamine oxidase inhibitors)
- Nelfinavir
- Nicotine patches
- Orphenadrine
- Ritonavir
- Certain steroids
- Theophylline
- Thiotepa.
What Medical Conditions Can Serve as a Contra-Indication to Using Zyban?
Inform your therapist prior to the beginning of treatment with Zyban if you have:
- Epilepsy or seizures
- A brain tumor
- A history of head trauma or physical brain injury
- Diabetes
- Any eating disorder (bulimia, anorexia, etc)
- Manic depression (bipolar disorder) or a history of bipolar disorder in members of your family
- Any heart disorder
- A recent history of stroke or heart attack
- A history of suicide attempts or suicidal thoughts
- Liver disorders, such as cirrhosis or a history of liver failure
- Kidney disorders, such as a history of renal failure
- Allergy, including allergic reaction to any foods, food colorings or preservatives.
You should also tell your therapist if you are:
- Pregnant or planning to become pregnant
- Breastfeeding a baby
- Drinking alcoholic beverages regularly.
Always inform your healthcare provider about any other medicines, vitamins or dietary supplements that you are currently taking before starting the therapy with Zyban.
Are There Any Alternatives to Zyban?
Zyban may be replaced by an alternative medication in case the person taking is susceptible to its side effects or doesn't find it effective. The examples of such alternatives include, but are not limited to:
- Nicotine products (nicotine patches, inhalers, gum, or lozenges)
- Varenicline, a non-nicotine drug used in the course of smoking cessation therapy.
There are some patients that prefer taking Wellbutrin SR to taking Zyban since this medication has similar effects but in most cases is more likely to be covered by insurance.
Most cases of therapy with Zyban also include various types of smoking cessation counseling.
What Should I Do in Case of Overdose with Zyban?
The symptoms of overdose with Zyban may include the following conditions:
- Seizures
- Hallucinations
- Fainting
- Tachycardia (increased heart rate)
- Arrhythmia (irregular heart rate)
- Fever
- Muscle constriction, pain, and damage
- Hypotension (decreased blood pressure)
- Breathing disorders
- Coma
- Death.
In case of overdose with Zyban, seek emergency medical attention.
What Are the Storage Regulations for Zyban?
Store Zyban at room temperature, in a dry dark place located out of reach of children.
What Should I Do in Case I Miss a Dose of Zyban?
If you fail to take a scheduled dose of Zyban in time, take it as soon as remembered. However, if it's almost the time for the next dose, simply skip the missed one and continue the treatment according to your usual schedule. Never double the dose of this medication!
Available Forms of Zyban
Zyban pills are currently available in one strength option – Zyban 150 mg tablets.
Is Zyban Available in the Form of a Generic Medication?
At the moment there are both generic and brand-name licensed versions of Zyban available in the market. The generic versions of Zyban include the medications sold under the names Bupropion SR tablets and Buproban tablets.
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