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Tramadol/Acetaminophen
Tramadol/Acetaminophen is a medication available by prescription used as a short-term pain-killer. The medication is a combination of two agents – an opioid related to codeine and an uncontrolled substance, relieving pain and reducing fever. It is manufactured in the form of pills and is usually prescribed to be taken every four to six hours as the need arises. The length of treatment course should not exceed five days.
What Is Tramadol/Acetaminophen and How Does It Work?
Tramadol/Acetaminophen (Ultracet®) is a medicine used for a short period of time (5 days or less) to treat painful conditions. The drug under the US law does not belong to the class of controlled substances, but it still might be abused.
Possible Side Effects of Therapy with Tramadol/Acetaminophen
Tramadol/Acetaminophen possesses a certain number of possible side effects. Though, far not all the people undergoing the therapy actually experience its side effects. The majority of experienced side effects are minor ones, so they may either be treated by your therapist or you yourself.
Below is the list of common side effects:
- Drowsiness
- Constipation
- Increased sweating
- Diarrhea
- Nausea
- Dizziness.
What Medical Conditions Can Serve as a Contra-Indication to Using Tramadol/Acetaminophen?
Before taking the drug do not forget to mention it to you healthcare provider if you have any of the following:
- Seizures or epilepsy
- A history of drug or alcohol dependence
- A head injury or high intracranial pressure
- Kidney disease, such as kidney failure (renal failure)
- Liver disease, such as cirrhosis, liver failure, or hepatitis
- Any allergies, including allergies to foods, dyes, or preservatives.
Also talk to your healthcare provider if you are:
- Pregnant or thinking about getting pregnant
- Breastfeeding a baby.
Do not forget to tell your healthcare provider about any other drugs you take, controlled or over-the-counter ones, including such substances as vitamins or herbal supplements.
In What Way Does Tramadol/Acetaminophen Work?
Hydrocodone/APAP is a combination two different drugs: Acetaminophen and Tramadol hydrochloride. Tramadol is classified as an opioid pain reliever. Clinical tests have not revealed the exact way in which Tramadol works to lull the pain. One of its metabolites makes the opioid receptors numb (the effect similar to that of morphine) and it may also affect the brain chemicals like serotonin and norepinephrine.
Acetaminophen ("APAP") is an uncontrolled non-prescription pain killer and a medication used to reduce body temperature and to fight fever. The combination of these two constituents increases the effectiveness of the medication.
How Do I Take Tramadol/Acetaminophen?
Here is the usual instruction on how and when Tramadol/Acetaminophen should be taken:
- The drug is produced in the form of pills which are usually prescribed to be taken every four to six hours depending on the intensity of pain and not exceeding the maximum dose per day.
- Do not take more medication than stated as a maximum daily dose, as this may result in overdosing identifiable by certain symptoms or poisoning by acetaminophen, which is able to cause liver failure.
- Take Tramadol/Acetaminophen only when it is needed depending on the intensity of pain. If you feel no pain, do not take the dose.
- Tramadol/Acetaminophen intake does not depend on the food intake. However its intake with food may slightly delay its effect in easing pain. If it causes you a syndrome of upset stomach try taking it along with meal or have a quick bite to eat when you take it in.
- Do not violate your prescription by increasing the dose on your own. If you have taken the drug for some time already, do not just stop taking it. Do so only when you are under your therapist's supervision.
Tramadol/Acetaminophen Dosage
Your healthcare provider will set up the dosage for you, and that will depend on a number of factors:
- Your age
- Your sensitivity to Tramadol/Acetaminophen
- Other drugs you take
- Whether you do or do not have any other health disorders.
You are not recommended to change the dosing scheme unless you're told to do so by your healthcare provider.
Possible Drug Interactions with Tramadol/Acetaminophen
Tramadol/Acetaminophen (Ultracet®) in the course of the therapy might interact with a certain number of other medications and substances, which are as follows:
- Alcoholic beverages
- Antihistamines (including many allergy, sleep, and motion sickness medications)
- Antipsychotics
- Barbiturate medications, including, but not limited to:
- Butalbital (Fioricet®, Fiorinal®)
- Pentobarbital (Nembutal®)
- Phenobarbital (Luminal®)
- Secobarbital (Seconal®)
- Benzodiazepines, such as:
- Alprazolam (Xanax®, Xanax XR®)
- Chlordiazepoxide (Librium®, Limbitrol®, Librax®)
- Clonazepam (Klonopin®)
- Clorazepate (Tranxene®)
- Diazepam (Valium®)
- Estazolam (ProSom®)
- Flurazepam (Dalmane®)
- Lorazepam (Ativan®)
- Midazolam (Versed®)
- Temazepam (Restoril®)
- Triazolam (Halcion®)
- Buspirone (Buspar®)
- Cyclobenzaprine (Flexeril®)
- Meperidine (Demerol®)
- Mirtazapine (Remeron®)
- Monoamine oxidase inhibitors (MAOIs), including:
- Isocarboxazid (Marplan®)
- Phenelzine (Nardil®)
- Rasagiline (Azilect®)
- Selegiline (Eldepryl®, Emsam®, Zelapar®)
- Tranylcypromine (Parnate®)
- Narcotics or opiates, such as morphine (MS Contin®, MSIR®), oxycodone, or codeine
- Other products that contain acetaminophen, including many prescription and non-prescription pain killers and cold or cough products
- Sibutramine (Meridia®)
- Sleep medications
- SSRI or SNRI antidepressants, including:
- Citalopram (Celexa®)
- Duloxetine (Cymbalta®)
- Desvenlafaxine (Pristiq™)
- Escitalopram (Lexapro®)
- Fluoxetine (Prozac®, Sarafem®)
- Fluvoxamine (Luvox®, Luvox® CR)
- Paroxetine (Paxil®, Paxil CR®)
- Sertraline (Zoloft®)
- Venlafaxine (Effexor®, Effexor XR®)
- St. John's wort
- Trazodone (Desyrel®)
- Tricyclic antidepressants, including:
- Amitriptyline (Elavil®)
- Amitriptyline and chlordiazepoxide (Limbitrol®)
- Amitriptyline and perphenazine (Etrafon®)
- Amoxapine (Asendin®)
- Clomipramine (Anafranil®)
- Desipramine (Norpramin®)
- Doxepin (Sinequan®)
- Imipramine (Tofranil®)
- Maprotiline (Ludiomil®)
- Nortriptyline (Pamelor®)
- Protriptyline (Vivactil®)
- Trimipramine (Surmontil®)
- Almotriptan (Axert®)
- Eletriptan (Relpax®)
- Frovatriptan (Frova®)
- Naratriptan (Amerge®)
- Rizatriptan (Maxalt®)
- Sumatriptan (Imitrex®) or sumatriptan/naproxen sodium (Treximet™)
- Zolmitriptan (Zomig®)
What Should I Do in Case of Overdose with Tramadol/Acetaminophen?
The symptoms of overdose are:
- Extreme drowsiness, leading to coma
- Cold, clammy skin
- Difficulty breathing
- Nausea and vomiting
- Sweating
- Liver failure
- Seizures
- Cardiac arrest
- Death.
If you happen to overdose, run for medical help.
What Should I Do in Case I Miss a Dose of Tramadol/Acetaminophen?
As this drug is usually taken at the pangs of pain it is not necessary to take it unless you really feel a surge of pain. If you do, take the skipped dose immediately. Make sure there is a gap between this dose and the next one.
How Should I Store Tramadol/Acetaminophen?
Tramadol/Acetaminophen should be kept away from heated and humid environments and out of the range of children's reach. Also be sure it is stored in a place where no one aiming at abusing the drug can get it.
Is Tramadol/Acetaminophen Available in the Form of a Generic Medication?
Tramadol/Acetaminophen is manufactured and can be bought in a form of generic medication.
Who Manufactures Tramadol/Acetaminophen?
Tramadol/Acetaminophen in its brand-name version is produced by Ortho-McNeil Pharmaceutical, Inc. and Janssen Ortho, LLC. A number of different manufacturers are licensed to produce the generic form of the drug.
What Strengths of Tramadol/Acetaminophen Are Available?
Tramadol/Acetaminophen is manufactured only in one strength - 37.5 mg of Tramadol hydrochloride and 325 mg of Acetaminophen per pill.
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