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Prozac

Prozac is representative of selective serotonin reuptake inhibitors class of drugs used in the course of treatment of such disorders as depression, panic disorder, obsessive-compulsive disorder, and bulimia. Side effects as with any other medication may be encountered in the course of Prozac treatment; they include such states as headache, diarrhea, and loss of appetite.

What Is Prozac and What Is It Used For?

Prozac® (fluozentine hydrochloride) is a drug available by prescription used in the treatment of various brain dysfunctions.

Who Manufactures Prozac?

Prozac is produced by Eli Lilly and Company
Its generic version is also manufactured by several independent producers.

What are the Medical Conditions Treated With Prozac?

Prozac is used to cure the following dysfunctions:

• Depression
• Obsessive-compulsive disorder (OCD)
• Bulimia
• Panic disorder.

There exists a different brand-name version of the drug called Sarafem®. Its constituents are the same that those of Prozac and the indications for its use include also premenstrual dysphoric disorder (PMDD). Prozac is not licensed to cure this state though.

In What Way Does Prozac Work?

Being a representative of selective serotonin reuptake inhibitors class of drugs, or SSRIs, it acts according to the general scheme of this class, influencing serotonin, the chemical of the brain tissue involved in the process of transmitting the nerve signal from cell to cell.

In the process of transmitting the nerve signal serotonin is released by the transmitting cell into the inter-cellar gap, so that it could influence the receptors of the adjacent cell and the signal would be passed over. In normal conditions the "reuptake" takes place, when the first cell absorbs extra serotonin left after the signal was transferred.

The unbalanced serotonin level is a reason for the development of various medical disorders, i.e. depression. Prozac acts by blocking the reuptake of the chemical, so more of it stays in the inter-cellar gap and consequently it can better activate the receptors or the next nerve cell.

What Effects Does Prozac Have?

Depression
The research data has proved Prozac to be effective in curing children's from eight years of age, teens' and adults' depressions. Long-acting Prozac was found to be more effective when applied to adults.

OCD
28 percent of patients who underwent Prozac treatment have admitted its effectiveness in curing obsessive-compulsive disorder. There were no reports of worsening of OCD, compared to 8 percent of those reports from the patients not going through the treatment. Children's and teens' treatment also proved to be effective.

Bulimia
Adults suffering from bulimia may also be treated with Prozac, the curing effect of which would be visible within a week, even faster than those of anti-depression Prozac therapy. What is also important is that Prozac is effective against bulimia even in those patients who do not suffer from depression. There were no studies of the effect of Prozac on children's and teens' bulimia.

Panic Disorder
62 percent of the members of the test group have claimed to be freed of panic attacks as a result of treatment with Prozac, which is significantly more than 44 percent of similar reports from those who didn't undergo the therapy. Curing effect on children's and teens' panic disorder was not studied.

How Do I Take Prozac?

Generally the recommendations on the intake schedule are the following:

• Prozac is available in the forms of capsules and oral liquid. Usually it is prescribed to be taken in orally one or two times a day.
• Prozac Weekly (the version, producing the longer effect) could also be bought. This version is prescribed to be taken orally only once a week. The capsules should be swallowed whole, do not chew, open or crush them.
• If Prozac causes drowsiness, take it before going to bed. If the effect is opposite, namely insomnia, it is better to be taken in the morning.
• The drug is not food dependant, though if it provokes the syndrome of upset stomach try taking it in the course of a meal.
• The intake time should be the same each day (same day of the week for Prozac Weekly), so that you have an even level of the drug in your blood.
• Do not violate the prescription or stop taking the drug, otherwise, it would not produce the desired effect.

Prozac Dosage

There are a number of factors which might influence the prescription of your healthcare provider. They are as follows:

• The kind of medical condition under treatment
• The age of the patient
• Other drugs taken in along with Prozac
• Other dysfunctions the patient has.

It is recommended to stick to the dosage prescribed by your healthcare provider and not to adjust it without his instruction to or his permission.

Possible Side Effects of Therapy with Prozac

As any other antidepressant Prozac can produce certain side effects. However it is not necessarily that every patient experiences them, even on the contrary it is a drug that is usually well-tolerated and in most cases, when it does produce side effects, they are minor and might be cured by the patient himself or his healthcare provider. The list below names the most common side effects:

• Insomnia
• Sleepiness and drowsiness
• Headache
• Nausea
• Diarrhea
• Loss of appetite
• Anxiety
• Dry mouth
• Hair loss.

Possible Drug Interactions with Prozac

A number of other drugs, such as lithium, seizure medications, triptants, etc may cause unwanted effects due to their interaction with Prozac® (fluoxetine hydrochloride). The drug levels in the patient's blood can increase thus stimulating the development of side effects.

The list of possible drug interactions includes but is not limited to:

• Alpazolam (Xanax®)
• Aspirin
• Certain antipsychotic medications, including:

• Clozapine (Clozaril®)
• Haloperidol (Haldol®)
• Pimozide (Orap®)
• Thioridazine (Mellaril®)

• Certain seizure medications, including carbamazepine (Tegretol®) and phenytoin (Diltantin®)
• Diazepam (Valium®)
• Digoxin (Digitek®, Lanoxin®)
• Linezolid (Zyvox®)
• Lithium (Eskalith®, Lithobid®)
• Monoamine oxidase inhibitors (MAOIs), including:

• Isocarboxazid (Marplan®)
• Phenelzine (Nardil®)
• Rasagiline (Azilect®)
• Selegiline (Eldepryl®, Emsam®, Zelapar®)
• Tranylcypromine (Parnate®)

• Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

• Ibuprofen (Motrin®, Advil®)
• Naproxen (Naprosyn®) or naproxen sodium (Aleve®,Anaprox®, Naprelan®)
• Diclofenac (Cataflam®, Voltaren®)
• Indomethacin (Indocin®)
• Nabumetone (Relafen®)
• Oxaprozin (Daypro®)
• Celecoxib (Celebrex®)
• Meloxicam (Mobic®)
• Etodolac (Lodine®)
• Ketoprofen (Orudis®)
• Ketorolac (Toradol®)

• Other SSRI or SNRI antidepressants, such as:

• Citalopram (Celexa®)
• Duloxetine (Cymbalta®)
• Escitalopram (Lexapro®)
• Paroxetine (Paxil®)
• Fluvoxamine (Luvox®)
• Sertraline (Zoloft®)
• Venlafaxine (Effexor®)

• St. John's wort
• Tramadol (Ultram®, Ultracet®)
• Tricyclic antidepressants, including:

• Amitriptyline (Elavil®)
• Amoxapine (Asendin®)
• Clomipramine (Anafranil®)
• Desipramine (Norpramin®)
• Doxepin (Sinequan®)
• Imipramine (Tofranil®)
• Maprotiline (Ludiomil®)
• Nortriptyline (Pamelor®)
• Protriptyline (Vivactil®)
• Trimipramine (Surmontil®)

• Triptans, including:

• Almotriptan (Axert®)
• Eletriptan (Relpax®)
• Frovatriptan (Frova®)
• Naratriptan (Amerge®)
• Rizatriptan (Maxalt®)
• Sumatriptan (Imitrex®)
• Zolmitriptan (Zomig®)

• Tryptophan
• Warfarin (Coumadin®, Jantoven®).

What Medical Conditions Can Serve as a Contra-Indication to Using Prozac?

Before taking Prozac make sure to notify your healthcare provider if you experience any of the following medical conditions:

• Bipolar disorder (aka manic depression), actual or in the family history
• A history of suicide attempts or suicidal thoughts
• A heart disease or a recent heart attack
• Diabetes
• Seizures or epilepsy
• Suicidal thoughts
• Liver disease, including liver failure or cirrhosis
• Allergies, including allergies to food, dyes, or preservatives.

Also don't forget to mention to your healthcare provider if you are:

• Pregnant or planning to get pregnant in near future
• Breastfeeding a baby.

Also let your healthcare provider know what other medications you take, including those belonging to the group of controlled as well as over-the-counter ones, vitamins and herbal supplements.

Other Medications Having Similar Effect and Indications

Even the most severe depression can be treated successfully. As in case of any other dysfunction, the earlier you start the treatment, the more effective it would be and the less chances of relapse there would be. Common methods used against depression are antidepressant medical treatment or psychotherapy or "talk therapy". If a patient suffers from severe depression, he may be prescribed to undergo the course of electroconvulsive therapy (ECT). There also exist different complimentary and alternative anti-depression treatments.

Prozac along with being well tolerated has proved to be effective in the majority of cases. Though, there is always a possibility of the occurrence of side effects or interaction with other medications. To avoid those named your therapist may recommend substitute medications which are listed below:

• Other selective serotonin reuptake inhibitors (SSRIs)
• Serotonin-norepinephrine reuptake inhibitors(SNRIs)
• Norepinephrine and dopamine reuptake inhibitors (NDRIs)
• Tricyclic antidepressants
• Monoamine oxidase inhibitors (MAOIs).

What Should I Do in Case of Overdose with Prozac?

Overdose of the drug has the following symptoms:

• Confusion
• Nervousness
• Breathing problems
• Dizziness
• Shakiness
• High blood pressure (hypertension)
• Low blood pressure (hypotension)
• Strange behavior
• Irregular heart rhythm (arrhythmia)
• Fever
• Fainting or temporary loss of consciousness
• Coma
• Death.

If you suffer an overdose, call for immediate professional medical help.

How Should I Store Prozac?

Prozac should be stored in a proper tightly closed container away from heated and humid environments and out of the range of children's reach.

What Should I Do in Case I Miss a Dose of Prozac?

In case a dose of Prozac is missed, it should be taken as soon as you remember this. If it is close to the time when you have to take the next dose, then skip the missed one and stick to your usual schedule. Never take a double dose of Prozac trying to make up for the skipped one.

What Strengths of Prozac Are Available?

There're currently three strengths of Prozac capsules available:

• Prozac 10 mg
• Prozac 20 mg
• Prozac 40 mg
• Prozac Weekly 90 mg.

There is only one strength available for Prozac in the form of the oral liquid: Prozac oral solution 20 mg per 5 mL (20 mg per teaspoonful).

Is Prozac Available in the Form of a Generic Medication?

Prozac is now manufactured both in the form of generic medication and in the form of the brand-name one. However, there is only the brand-name version of Prozac Weekly licensed for sale.

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