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Paxil

Paixil is selective serotonin reuptake inhibitor licensed to be used in the treatment of mental disorders like depression, obsessive-compulsive disorder, and panic disorder. Its effect is based on its ability to balance the quantity of certain chemicals in the brain tissue. Paxil, either in the form of pills or in the liquid one, is prescribed to be taken one dose a day. It may provoke side effects such as ejaculation problems, nausea, and drowsiness.

What Is Paxil And How Does It Work?

Paxil® (paroxetine hydrochloride) is a medication available on prescription and used in the treatment of several brain dysfunctions.

Who Manufactures Paxil?

Paxil in generic form is produced by different manufacturers; the brand-name version is made by GlaxoSmithKline.

What are the Medical Conditions Treated With Paxil?

Paxil is used to cure several different conditions which are as follows:

  • Major depression or clinical depression)
  • Obsessive-compulsive disorder (OCD)
  • Panic disorder
  • Social anxiety disorder
  • Generalized anxiety disorder (GAD)
  • Post-traumatic stress disorder (PTSD).

In What Way Does Paxil Work?

Paxil belongs to the group of selective serotonin reuptake inhibitors, or SSRIs. They are called so because they primarily influence serotonin, the brain chemical which serves as a mediator to send signals between the nerve cells.

In the course of the nerve signal transmission, one of the cells releases serotonin, which enters the space in between that cell and then the adjacent one. The chemical reaches the ends of the cell, irritates the receptors and thus the signal is transferred. This is followed by so-called "reuptake" when the first cell absorbs extra serotonin back.

The unbalanced amount of serotonin, which is the result of a dysfunction, might cause different conditions, for instance, depressions. The basic effect of Paxil is that it blocks the reuptake of the chemical which results in the more effective transmission of the signals.

How Effective Is Paxil?

Paxil is an effective means of treatment of several conditions.

Depression
It is used as a remedy for depression in adults. According to the clinical research, it can also prevent the relapse – the comeback of depression.

OCD
Obsessive-Compulsive Disorder (OCD) is also treated with Paxil. The rate of improvement showed at clinical tests is 24 percent.

Panic Disorder
Paxil is an effective remedy for panic disorder in adults. 76 percent of people who have undergone treatment stopped suffering from panic attacks.

Social Anxiety Disorder
Paxil showed 77 percent of effectiveness by adults with social anxiety disorder.

Generalized Anxiety Disorder (GAD)
According to the results of the studies, people undergoing the Paxil therapy have started experiencing improvement in the anxiety syndromes. Paxil also proved to be able to prevent relapse.

Post-Traumatic Stress Disorder (PTSD)
Adults suffering from PTSD and treaded with Paxil reported that they felt that their condition has improved as Paxil has reduced PTSD symptoms.

How Do I Take Paxil?

The following list contains general instructions on how Paxil should be taken if prescribed:

  • Paxil, as it is manufactured in the form of pills as well as in the one of suspension, is taken orally once a day.
  • The suspension should be shaken well before each intake
  • In case Paxil provokes the feeling of drowsiness, try taking your dose right before going to sleep. If the effect is the opposite and it causes insomnia, take your dose in the morning, as most patients do.
  • Paxil intake doesn't depend on meals. If it causes the syndrome of upset stomach, try combining it with food.
  • Schedule specific time to take your daily dose, so that even concentration of the medication would be preserved in your blood.
  • Do not violate the prescription or stop the therapy.

Paxil Dosage

Your healthcare provider will set up the dosage for you, and that will depend on a number of factors:

  • Your age
  • Whether you do or do not take any other medications
  • The kind of disorder cured
  • Whether you do or do not have any other health disorders.

You are not recommended to change the dosing scheme unless you're told to do so by your healthcare provider.

Possible Side Effects of Therapy with Paxil

As any other drug Paxil is not free of side effects, though they do not always accompany the intake of this medication. Moreover, the majority of patients undergoing the Paxil therapy do not encounter any problems, as even if the side effects occur, they take minor forms and can be easily cured by the patient himself or with the help of his healthcare provider. Serious side effects are fewer in number and less frequently encountered. The following list shows the most common side effects of Paxil:

  • Ejaculation problems
  • Nausea
  • Insomnia
  • Drowsiness
  • Weakness
  • Dry mouth
  • Headache
  • Constipation.

Possible Drug Interactions with Paxil

Paxil® (paroxetine hydrochloride) in the course of the therapy might interact with a certain number of other medications and substances, which are as follows:

  • Alcohol
  • Aspirin
  • Atomoxetine(Strattera®)
  • Certain arrhythmia medications, including propafenone (Rythmol®), flecainide (Tambocor®), and quinidine
  • Certain seizure medications, including phenobarbital (Luminal®) andphenytoin (Dilantin®)
  • Cimetidine (Tagamet®)
  • Digoxin (Digitek®, Lanoxin®)
  • Linezolid (Zyvox®)
  • Lithium (Eskalith®, Lithobid®)
  • Monoamine oxidase inhibitors (MAOIs), including:
    • Isocarboxazid (Marplan®)
    • Phenelzine (Nardil®)
    • Rasagiline (Azilect®)
    • Selegiline (Eldepryl®, Emsam®, Zelapar®)
    • Tranylcypromine (Parnate®)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
    • Ibuprofen (Motrin®, Advil®)
    • Naproxen (Naprosyn®) or naproxen sodium (Aleve®,Anaprox®, Naprelan®)
    • Diclofenac (Cataflam®, Voltaren®)
    • Indomethacin (Indocin®)
    • Nabumetone (Relafen®)
    • Oxaprozin (Daypro®)
    • Celecoxib (Celebrex®)
    • Meloxicam (Mobic®)
    • Etodolac (Lodine®)
    • Ketoprofen (Orudis®)
    • Ketorolac (Toradol®)
  • Phenothiazine medications, including:
    • Chlorpromazine
    • Fluphenazine (Prolixin®)
    • Perphenazine
    • Promethazine (Phenergan®)
    • Thioridazine (Mellaril®)
    • Trifluoperazine
  • Pimozide (Orap®)
  • Procyclidine (Kemadrin®)
  • Risperidone (Risperdal®)
  • Other SSRI or SNRI antidepressants, such as:
    • Citalopram (Celexa®)
    • Duloxetine (Cymbalta®)
    • Escitalopram (Lexapro®)
    • Fluoxetine (Prozac®, Sarafem®)
    • Fluvoxamine (Luvox®)
    • Paroxetine controlled release (Paxil CR®)
    • Sertraline (Zoloft®)
    • Venlafaxine (Effexor®, Effexor XR®)
  • St. John's wort
  • Tamoxifen (Nolvadex®)
  • Theophylline
  • Tramadol (Ultram®, Ultracet®)
  • Tricyclic antidepressants, including:
    • Amitriptyline (Elavil®)
    • Amoxapine (Asendin®)
    • Clomipramine (Anafranil®)
    • Desipramine (Norpramin®)
    • Doxepin (Sinequan®)
    • Imipramine (Tofranil®)
    • Maprotiline (Ludiomil®)
    • Nortriptyline (Pamelor®)
    • Protriptyline (Vivactil®)
    • Trimipramine (Surmontil®)
  • Triptans, including:
    • Almotriptan (Axert®)
    • Eletriptan (Relpax®)
    • Frovatriptan (Frova®)
    • Naratriptan (Amerge®)
    • Rizatriptan (Maxalt®)
    • Sumatriptan (Imitrex®)
    • Zolmitriptan (Zomig®)
  • Tryptophan
  • Warfarin (Coumadin®, Jantoven®).

What Medical Conditions Can Serve as a Contra-Indication to Using Paxil?

You should inform your doctor if you have any conditions out of the following:

  • Bipolar disorder or a family history of this condition (also known as manic depression)
  • A history of suicide attempts or suicidal thoughts
  • A recent history of a heart attack or if you have unstable heart disease
  • Diabetes
  • Seizures or epilepsy
  • Glaucoma (a condition of the eyes)
  • Liver disease, including liver failure or cirrhosis
  • Kidney problems, including kidney failure (renal failure)
  • Allergies of any kind, including allergies to food, dyes, or preservatives.

Don't forget to let your doctor know if you are:

  • Pregnant or planning to get pregnant in near future
  • Breastfeeding a baby.

As well give him the fullest information possible on what drugs, controlled or available on free sale, vitamins, antacids, herbal food additives you take at the moment.

Are There Any Drugs That Can Substitute Paxil?

Depression, even if it is severe, is a curable dysfunction and the earlier you start to treat it, the more effective the treatment would be, and there would be smaller chance of relapse.

Even though there exist complementary and alternative treatments for depression, the most common one is still taking special medications (antidepressants) and a verbal therapy carried out by psychologist or psychotherapist (psychotherapy). If depression is severe it might also be an option that your doctor recommends you electroconvulsive therapy (ECT).

Paxil is not only quite effective in treating depression; it is also well tolerated by most people. However, depending on the individual characteristics of the state treated and the patient, side effects may occur, in which case your doctor will find it necessary to recommend you an alternative drug of similar effect. Below there is a list of possible options for such substitution:

  • Other selective serotonin reuptake inhibitors (SSRIs)
  • Serotonin-norepinephrine reuptake inhibitors(SNRIs)
  • Norepinephrine and dopamine reuptake inhibitors (NDRIs)
  • Tricyclic antidepressants
  • Monoamine oxidase inhibitors (MAOIs).

What Should I Do in Case of Overdose with Paxil?

The overdose with Paxil might have any or the combination of any of the following symptoms:

  • Nausea and vomiting
  • Shakiness (tremor)
  • Rapid heart rate (tachycardia) or slow heart rate (bradycardia)
  • Confusion
  • Dizziness
  • Seizures
  • Irregular heart rhythm (arrhythmia)
  • High blood pressure (hypertension) or low blood pressure (hypotension)
  • Aggressiveness
  • Fainting
  • Muscle pain or muscle stiffness
  • Liver problems, including hepatitis
  • Kidney failure
  • Coma
  • Death.

In case you overdose, run for immediate professional medical help.

How Should I Store Paxil?

Paxil should be stored in a proper container at the room temperature away from moisture, and out of children's reach.

What Should I Do in Case I Miss a Dose of Paxil?

Take your dose as soon as you remember that you've missed one, unless it is time for the next, in which case just continue according to your usual scheme. Never double a dose to make up for the one you've skipped.

What Strengths of Paxil Are Available?

Paxil pills are available for purchase in the following strengths:

  • Paxil 10 mg
  • Paxil 20 mg
  • Paxil 30 mg
  • Paxil 40 mg.

There is only one strength available for the oral liquid - Paxil oral suspension 10 mg per 5 mL (10 mg per teaspoonful).

Is Paxil Available in the Form of a Generic Medication?

Right now both Paxil in the form of pills and in that of oral liquid are available for purchase in the brand-name as well as in the generic forms.

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