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Meridia
Meridia is a medication available by prescription licensed to be used as a part of weight-loss treatment. It is manufactured in the capsule form and prescribed to be taken once a day. Its effect is based on its ability to interact with chemicals contained in the brain tissue thus creating the sense of fullness. Side effects, as with any medication, are possible and might include such states as headaches, insomnia and constipation.
What Is Meridia And How Does It Work?
Meridia® (sibutramine hydrochloride monohydrate) is a prescription drug licensed to be used as a weigh-loss stimulator. It not only makes patients lose weight, but also has a proven ability to help them prevent gaining it back.
Who Manufactures Meridia?
The manufacturer of Meridia is Abbott Laboratories.
In What Way Does Meridia Work?
The basis of the Meridia's healing power is its ability to make a person feel full with less of food. It interacts with the brain chemicals (like serotonin, morepinephrine and dopamine), by increasing the amount of some of them in specific areas of the tissue. It does not boost the production of the chemicals though, but prevents their "reuptake". "Reuptake" is a phenomenon occurring between the two nerve cells while transmitting the nerve signal. The process of transmission of the signal is carried out with the help of the brain chemical, which first is released by the sending cell, then enters the gap between the nerve cells and then activates the receptors of the second cell, so that the impulse may continue to spread. When this is done, "reuptake" actually happens, if the first cell absorbs back extra chemical left in the space between the cells in order to prevent it from further holding active the second cell.
Meridia blocks serotonin, norepinephrine, and dopamine reuptake so that bigger amount of these chemicals stays in the inter-cellar gap which provides the chemicals with the possibility to activate the next nerve cell more intensely. This actually causes the signal to stop eating, as the sense of fullness is created, but at the same time it does not suppress appetite.
How Effective Is Meridia?
The clinical research showed that Meridia is an effective weight-loss stimulator. As a result of the six-month course of Meridia intake combined with diet, patients lost on average up to 18 pounds. Dieting for the same period of time brought only 2.9 pounds weight-loss. More weight was lost if bigger doses of the drug were taken. One-year study only proved these results.
During the research it was also proved that Meridia is effective for those who have already reached the desired weight to preserve it. According to the data, up to 43 percent of those undergoing the course of Meridia treatment combined with dieting kept off up to 80 percent of the weight they had lost after two years, which might be compared with only 3 percent of people who practiced only dieting.
The combination of Meridia intake and dieting has also proved to have positive effect on cholesterol levels, most likely as a consequence of the weight loss. The drop was observed in the levels of total cholesterol and the LDL cholesterol, while important HDL cholesterol levels got higher.
How Do I Take Meridia?
Generally, some major points about the intake schedule include the following:
- The capsule of Meridia is taken orally once a day.
- Its intake is not food-dependant, though to prevent the syndrome of upset stomach you can consider taking it with food.
- Meridia is most effective when combined with low-calorie diet, without which desired effect would not be produced.
- Following he prescription is essential for the result.
Meridia Dosage
Your doctor will prescribe you a dose of Meridia taking into consideration the following factors:
- Your body's response to Meridia
- Presence or absence of dangerous side effects
- Presence or absence of other health problems
- Other medications you take.
Be careful not to adjust the dose on your own, do so only if your therapist advises that.
Possible Side Effects of Therapy with Meridia
There's a list of side effects that might appear as a result of Meridia intake. Though, as it is always the case, not every patient encounters them, on the contrary, as Meridia is a well-tolerated drug, most of the side effects surfacing during the treatment are minor, which means they do not require any special medical help.
The list of side effects includes though is not limited to:
- Headaches
- Dry mouth
- Loss of appetite
- Constipation
- Insomnia.
Possible Drug Interactions with Meridia
Meridia® (sibutramine hydrochloride monohydrate) can interact with some other substances and drugs. The list of possible interactions includes but is not limited to:
- Certain antibiotics or antifungal medications
- Certain pain medications, including:
- Fentanyl (Actiq®, Duragesic®, Fentora™, Sublimaze®)
- Meperidine (Demerol®)
- Pentazocine (Talwin®)
- Tramadol (Ultram®, Ultracet®)
- Cough, cold, or allergy medications
- Ergot medications, such as:
- Bromocriptine (Parlodel®)
- Dihydroergotamine (Migranal®)
- Ergonovine
- Ergotamine (Bellamine S, Cafergot®, Ergomar®)
- Methylergonovine (Methergine®)
- Pergolide (Permax®)
- Lithium (Eskalith®, Lithobid®)
- Monoamine oxidase inhibitors (MAOIs), including:
- Isocarboxazid (Marplan®)
- Phenelzine (Nardil®)
- Rasagiline (Azilect®)
- Selegiline (Eldepryl®, Emsam®, Zelapar®)
- Tranylcypromine (Parnate®)
- Other weight-loss medications
- SSRI or SNRI antidepressants, such as:
- Citalopram (Celexa®)
- Duloxetine (Cymbalta®)
- Escitalopram (Lexapro®)
- Fluoxetine (Prozac®, Sarafem®)
- Paroxetine (Paxil®, Paxil CR®)
- Fluvoxamine (Luvox®)
- Sertraline (Zoloft®)
- Venlafaxine (Effexor®, Effexor® XR)
- St. John's wort
- Tricyclic antidepressants, including:
- Amitriptyline (Elavil®)
- Amoxapine (Asendin®)
- Clomipramine (Anafranil®)
- Desipramine (Norpramin®)
- Doxepin (Sinequan®)
- Imipramine (Tofranil®)
- Maprotiline (Ludiomil®)
- Nortriptyline (Pamelor®)
- Protriptyline (Vivactil®)
- Trimipramine (Surmontil®)
- Almotriptan (Axert®)
- Eletriptan (Relpax®)
- Frovatriptan (Frova®)
- Naratriptan (Amerge®)
- Rizatriptan (Maxalt®)
- Sumatriptan (Imitrex®)
- Zolmitriptan (Zomig®)
What Medical Conditions Can Serve as a Contra-Indication to Using Meridia?
Prior to starting Meridia therapy be sure to inform your doctor if you have any of the following:
- High blood pressure (hypertension)
- Any heart problems
- A history of stroke
- Liver disease, liver failure, cirrhosis, or hepatitis
- Kidney disease, including kidney failure
- Glaucoma
- Seizures or epilepsy
- A bleeding disorder
- Had problems with gallstones
- Depression
- An eating disorder, such as anorexia nervosa or bulimia
- Drug or alcohol addiction in the past
- Any allergies, including allergies to food, dyes, or preservatives.
Make sure the therapist knows that you are:
- pregnant or planning to get pregnant in near future
- breastfeeding a baby.
He also has got to know about all the medical products you take, either available by or without a prescription, vitamins, food additives or herbal supplements.
What Should I Do in Case of Overdose with Meridia?
The symptoms of overdose are the following:
- Tachycardia (rapid heart beat)
- Hypertension (high blood pressure)
- Headaches
- Dizziness.
If you happen to take a large dose, go for immediate professional medical help.
How Should I Store Meridia?
Meridia capsules should be stored in an airtight container at room temperature, away from wet and hot environments, as well as out of the range of children's reach.
What Should I Do in Case I Miss a Dose of Meridia?
In case you miss a dose, simply skip it and go on taking Meridia as prescribed. Do not try to double the dose in order to make up for the skipped one.
What Strengths of Meridia Are Available?
The following strengths of Meridia are available:
- Meridia 5 mg
- Meridia 10 mg
- Meridia 15 mg.
Is Meridia Available in the Form of a Generic Medication?
Meridia is not available in the form of generic medication.
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