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Lorazepam
Lorazepam is a medication licensed to be used in the treatment of anxiety. Its anti-depression effect is based on its ability to influence the naturally calming brain chemical (gamma-aminobutyric acid or GABA) and enhance its soothing effect. Lorazepam, in any of its available forms – pills, oral liquid or injection – as any other medicine may produce side effects, among which there are fatigue, unsteadiness, weakness and dizziness.
What Is Lorazepam And How Does It Work?
Lorazepam (Ativan®), the representative of benzodiazepines group of medicines is an anti-depressant medication, available in three forms of pills, oral liquid and injections only by prescription. Apart from treating anxiety and lessening nervous tension, Lorazepam injections are also used to cure severe seizures (status epilepticus).
Who Manufactures Lorazepam?
Lorazepam is produced by Biovail Pharmaceuticals.
In What Way Does Lorazepam Work?
Being a representative of the group of medicines called benzodiazepines, Lorazepam shares their ability to produce the following effects on the human body:
- It educes anxiety
- Helps to fall asleep
- Provides relaxing effect over muscles
- Stops seizures
- Impairs short-term memory.
All the representatives of benzodiazepines group have practically the same effects, the intensity of which depends on the type of basic component in a particular drug. Benzodiazepines work by stimulating the effectiveness of GABA (gamma-aminobutyric acid), which is a natural compound capable of providing soothing effect and contained in human brain tissue. Gamma-aminobutyric acid is responsible for slowing down or blocking certain nerve signals sent by the human brain. Lorazepam and other benzodiazepines might be classified as sedatives, soft tranquilizers and CNS (central nervous system) depressants.
How Do I Take Lorazepam?
These are the keystones of Lorasepam treatment:
- Lorazepam is produced in three forms – pills, oral liquid suspension and injections. If an oral form is used, Lorazepam is usually prescribed to be taken twice of thrice a day, though sometimes it might as well be taken only before going to bed.
- Lorazepam intake does not depend on the meals. Though if it causes stomach discomfort, you might find it helpful to take it along with food.
- It is not recommended to violate the prescription, as overdosing might cause damage to your health.
Lorazepam Dosage
Your healthcare provider will set up a dose for you depending on the following factors:
- Your age
- Other health dysfunctions you have
- If you do or do not take any other drugs at the moment.
Do not try to adjust your dose on your own without your doctor's instruction.
Possible Side Effects of Therapy with Lorazepam
Being a medication Lorazepam obviously can produce certain side effects. However it is not necessarily that every patient experiences them, because it is a drug that is usually well-tolerated and in most cases when it does produce side effects they are minor and might be cured by the patient himself or his healthcare provider. The list below names the most common side effects, though it doesn't include all of them, so for a more complete list of less frequent and more serious side effects consult your doctor.
- Sleepiness or calming effect (as sedation)
- Dizziness
- Weakness
- Unsteadiness.
Possible Drug Interactions with Lorazepam
Do not forget to discuss possible interactions of another medical substances and medications with your doctor. The list of possible interactions goes below:
- Alcohol
- Anesthetics
- Antidepressant medications
- Antipsychotic medications, such as:
- Aripiprazole (Abilify®)
- Chlorpromazine (Thorazine®)
- Clozapine (Clozaril®, FazaClo®)
- Fluphenazine (Prolixin®)
- Olanzapine (Zyprexa®, Symbyax®)
- Perphenazine (Trilafon®)
- Paliperidone (Invega®)
- Quetiapine (Seroquel®)
- Risperidone (Risperdal®)
- Thioridazine (Mellaril®)
- Trifluoperazine (Stelazine®)
- Ziprasidone (Geodon®)
- Amobarbital (Amytal®)
- Butalbital (Fioricet®, Fiorinal®)
- Pentobarbital (Nembutal®)
- Phenobarbital (Luminal®)
- Secobarbital (Seconal®)
- Divalproex sodium (Depakote®, Depakote ER®, or valproic acid(Depakene®)
- Narcotics or opiates, such as morphine, oxycodone (OxyContin®), or hydrocodone (Lortab®, Vicodin®)
- Other benzodiazepines, including:
- Alprazolam (Xanax®)
- Chlordiazepoxide (Librium®, Limbitrol®, Librax®)
- Clonazepam (Klonopin®)
- Clorazepate (Tranxene®)
- Diazepam (Valium®)
- Estazolam (ProSom®)
- Flurazepam (Dalmane®)
- Midazolam (Versed®)
- Temazepam (Restoril®)
- Triazolam (Halcion®)
- Probenecid
- Seizure medications
- Sleep medications.
What Medical Conditions Can Serve as a Contra-Indication to Using Lorazepam?
Before starting Lorazepam treatment do not forget to mention to your doctor if you have any of the following medical disorders:
- Glaucoma
- A history of drug or alcohol abuse
- Depression
- Liver disease, including liver failure or cirrhosis
- Kidney disease, including kidney failure
- Any allergies, like allergies to food, dyes, or preservatives.
Also let your therapist know if you are:
- Pregnant or thinking of becoming pregnant
- Breastfeeding a baby.
Also inform your doctor about all the medications, controlled or over-the-counter ones, you take, including food additives, herbal supplements and vitamins.
What Should I Do in Case of Overdose with Lorazepam?
Overdose with Lorazepam has the following symptoms:
- Sleepiness
- Coma
- Confusion
- Speech problems
- Lethargy
- Hypotension
- Breath dysfunction
- Death.
If you have any of the symptoms above run for immediate professional help.
What Should I Do in Case I Miss a Dose of Lorazepam?
If you happen to miss a dose of Lorazepam it is necessary for you to take one as soon as you remember, unless it is time for the next dose, in which case just skip the dose you've missed and go on according to your regular intake schedule. Never try to make up for the missed dose by doubling the next.
What Strengths of Lorazepam Are Available?
Lorazepam in the form of tablets is generally available in three strengths:
- Lorazepam 0.5 mg
- Lorazepam 1 mg
- Lorazepam 2 mg.
The drug is also available in the form of oral liquid and in the form of injections.
Is Lorazepam Available in the Form of a Generic Medication?
At the moment you can buy both the generic and the licensed brand-name version of Lorazepam.
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