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Glugophage

Glucophage is a prescription medication used to treat type 2 diabetes by controlling the level of blood sugar. The medications aims at decreasing the level of sugar released by your liver. The drug is available in the form of tablets and should be taken once to thrice per day. The medication also comes in a long-acting extended-release form that s usually taken once a day with food in the evening. Some common side effects caused by Glucophage comprise nausea, diarrhea, indigestion.

What Is Glucophage And What Is It Used for?

Glucophage® (metformin) is prescribed to people suffering from type 2 diabetes (or noninsulin-dependent diabetes, or adult-onset diabetes). The drug is manufactured in the following forms:

• Extended-release tablet known under the name Glucophage XR® (metformin ER)
• Two long-acting tablets called Fortamet® and Glumetza®
• Liquid form known under the name Riomet®.

Who Manufactures Glucophage?

Glucophage, as well as Glucophage XR are made by Bristol-Myers Squibb. Generic version of the drug is produced by different manufacturers.

In What Way Does Glucophage Work?

The medication belongs to the group of diabetes drugs also called biguanide medications. Glucophage is used to lower the level of glucose produced by the liver and the level of sugar the body absorbs. It also makes insulin receptors sensitive, due to which body responds to insulin better. Thus all these processes result in lowered level of blood sugar.

Unlike some diabetes drugs, Glucophage doesn't cause hypoglycemia (extremely low blood sugar), as the drug doesn't increase the level of body insulin.

According to the results of the research, Glucophage is an effective treatment for type 2 diabetes. It's approved to lower the fasting blood sugar and HbAlc, which measures the control of long-term blood sugar. People who don't have diabetes have HbAlc level about 6%, those ones suffering from it have higher level of hemoglobin.

High HbAlc showings imply increased risk of development of long-term diabetes. These medical issues include heart disorder, diabetic retinopathy, diabetic neuropathy, diabetic nephropathy. Glucophage controls the level of blood sugar, thus lowering the risk of occurrence of such issues.

The research revealed some people may lose weight in the course of therapy with Glucophage.

How Do I Take Glucophage?

Bear in mind the following recommendations on the use of Glucophage:

• The drug is available in tablets. You should take it by mouth, once to trice a day. There's also the long-acting form of the medication, known under the name Glucophage XR, which you should take one time with food every evening.
• You are advised to take Glucophage with meal in order to avoid stomach ache.
• Do not break or crush the Glucophage XR tablet – swallow it whole
• In order to keep the level of the drug even in your blood, take it at the same time each day throughout the course of therapy
• Take Glucophage as prescribed and finish the full course of therapy, without stopping it even if you feel better.

Glugophage Dosage

Your therapist will recommend you the appropriate dosage of the medication. It depends on the following factors:

• The type of main diabetes therapy prescribed
• Other diseases you may have
• Other medicines you take currently.

Do not increase or decrease your dose unless your doctor tells you to do so.

Possible Side Effects of Therapy with Glucophage

There are some side effects caused by Glucophage. They are not serious and don't require special treatment. Serious side effects are reported by very few patients. Common ones include:

• Diarrhea
• Nausea
• Weakness
• Stomach ache
• Migraine
• Indigestion.

Possible Drug Interactions with Glucophage

The list of the medications Glucophage can interact with includes:

• Certain decongestants, such as phenylephrine (Sudafed PE®) or pseudoephedrine (Sudafed®)
• Calcium channel blockers, including:

• Amlodipine (Norvasc®)
• Diltiazem (Cardizem®, Dilacor®, Tiazac®)
• Felodipine (Plendil®)
• Isradipine (DynaCirc®)
• Nicardipine (Cardene®)
• Nifedipine (Adalat®, Procardia®)
• Nisoldipine (Sular®)
• Verapamil (Calan®, Verelan®)

• Cimetidine (Tagamet®)
• Corticosteroids, including:

• Betamethasone (Celestone®)
• Cortisone
• Dexamethasone (Decadron®)
• Fludrocortisone (Florinef®)
• Hydrocortisone (Cortef®)
• Methylprednisolone (Depo-Medrol®, Medrol®)
• Prednisolone (Ovapred®, Pediapred®)
• Prednisone
• Triamcinolone (Kenalog®, Aristospan®)

• Diuretics, such as:

• Acetazolamide (Diamox®)
• Amiloride (Midamor®)
• Bumetanide (Bumex®)
• Chlorothiazide (Diuril®)
• Chlorthalodone
• Ethacrynic acid (Edecrin®)
• Furosemide (Lasix®)
• Hydrochlorothiazide (Microzide®, HCTZ)
• Metolazone (Zaroxolyn®)
• Torsemide (Demadex®)
• Triamterene (Dyrenium®, Dyazide®, Maxzide®)

• Estrogens
• Isoniazid
• Niacin (nicotinic acid, Niaspan®, Niacor®, Nicolar®)
• Oral contraceptives (birth control pills)
• Phenothiazine medications, such as:

• Chlorpromazine
• Fluphenazine (Prolixin®)
• Perphenazine
• Promethazine (Phenergan®)
• Thioridazine (Mellaril®)
• Trifluoperazine

• Phenytoin (Dilantin®)
• Thyroid medications, including levothyroxine (Levothroid®, Levoxyl®, Synthroid®, Unithroid®), liothyronine (Cytomel®), thyroid (Armour Thyroid®), and Thyrolar®.

What Medical Conditions Can Serve as a Contra-Indication to Using Glucophage?

Inform your doctor if you have:

• Kidney disease (such as renal failure)
• Liver disease (such as liver failure or cirrhosis)
• Low vitamin B12 level
• Congestive heart failure
• Experienced a heart attack in the past
• Any health condition requiring surgery
• Any allergies.

Tell your therapist if you:

• Are pregnant or trying to become pregnant
• Are breastfeeding
• Drink alcohol frequently.

Do not forget to tell your doctor about all the medications you are taking.

Is There Any Alternative to Therapy with Glucophage?

Start treating type 2 diabetes with changes in your lifestyle, for example with weight loss therapy, diets, doing special exercises. If it's not effective, such medication as Glucophage might be really helpful.

Glucophage is responsible for decrease of the level of blood sugar, so it aims at lowering the risk of problems resulting from diabetes, including ones with eyesight, heart, nerves, kidney, and other various high blood sugar problems.

The drug is useful for many patients, as helps to control blood sugar properly. Most of patients tolerate it without any problems. If Glucophage causes side effects or doesn't work properly, take the medication with Avandia® or insulin. There are also other pharmaceutical products that can serve as substitutes for Glucophage.

What Should I Do in Case of Overdose with Glucophage?

Symptoms of overdose with this medication may include:

• Low blood sugar
• Lactic acidosis
• Weakness
• High heartbeat
• Confusion
• Irregular heartbeat
• Giddiness
• Cold
• Difficulties when breathing
• Pain in muscles
• Sweating.

If you notice you have some overdose symptoms, contact your therapist immediately.

How Should I Store Glucophage?

You should store the drug at room temperature, in a dry airtight container, away from children.

What Should I Do in Case I Miss a Dose of Glucophage?

In case you forget to take the dose of Glucophage in time, take it when you remember, unless it's already time for the next dose. In this case skip the missed one and go on taking the drug in full accordancw with your normal intake schedule. Never take a double dose of Glucophage.

Available Forms of Glucophage

Regular Glucophage comes in three different strengths:

• Glucophage 500 mg tablets
• Glucophage 850 mg tablets
• Glucophage 1000 mg tablets.

Glucophage XR comes in two strengths:

• Glucophage XR 500 mg tablets
• Glucophage XR 750 mg tablets.

Long-acting Glucophage 1000 mg tablets are known under the brand names of Fortamet and Glumetza. Liquid form of the medication is always available and is called Riomet.

Is Glucophage Available in the Form of a Generic Medication?

Glucophage and Glucophage XR are currently available for purchase while there are no generic versions of Fortamet, Glumetza, Riomet offered in the market.

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