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Bactrim is a licensed medication curing different types of bacterial infections. It helps people with weak immune system to avoid the risk of Pneumocystis carinii pneumonia. Two antibiotics within the drug are known to inhibit the release of folic acid in bacteria. Now Bactrim is available in the form of tablets, and as a rule is taken twice daily.
What is Bactrim and What Is It Used for?
Bactrim® (sulfamethoxazole/trimethoprim) is an antibiotic prescribed in order to cure various infections. In addition, the medication prevents Pneumocystis carinii pneumonia in those who have weak immune system.
There are two antibiotics in this drug. These are sulfamethoxazole and trimethoprim. The first one belongs to sulfonamides, also known as "sulfa" drugs, while trimethoprim isn't associated with any particular class of drugs. These antibiotic chemicals are known to produce different effect. They both inhibit the release of folic acid in bacteria, acting in different periods of its release. Folic acid is one of the chemicals responsible for producing proteins, as well as DNA. Bactrim slightly affects the cells of a body due to the fact that people get folic acid from diets.
The combination of such antibiotics as sulfamethoxazole with trimethoprim lowers the resistance of bacteria against antibiotics and increases antibiotic effectiveness.
Who Manufactures Bactrim?
Bactrim is a well-known medication produced by Mutual Pharmaceutical Company, Inc. and distributed by AR Scientific. Generic form of the drug is produced by various others manufacturers.
How Do I Take Bactrim?
You should be aware of the following general recommendations concerning the use of Bactrim:
- Bactrim is manufactured in tablet form and is generally taken by mouth, as a rule, twice daily. However the intake frequency changes from one tablet to four tablets per day.
- You may take Bactrim with or without food. In case you feel some discomfort in your stomach, take it with food.
- You may take the drug at any time during the day, but around the same time each day, which allows you to keep the level of the active component in your blood flow even. In case you should take it twice per day, try to do every 12 hours.
- Bactrim stops its effect as soon as you stop taking it. Follow all the instructions provided by your doctor.
Bactrim Dosage
Generally, the dose of the medication is adjusted by the therapist and depends on the following:
- Infection and types of bacteria causing it
- Your physical features (height and weight)
- Other medical conditions you might have
- Other medications that you take at the moment.
Don't change your dose without obtaining doctor's instruction to do so.
Possible Side Effects of Therapy with Bactrim
As a rule, possible side effects caused by Bactrim are minor and experienced just by some of the patients. Serious side effects are observed even rarer.
Common ones comprise:
- Nausea
- Vomiting
- Loss of appetite
- Itching
- Rashes.
Possible Drug Interactions with Bactrim
Bactrim is known to interact with other drugs, when taken alongside with them. Among these are:
- Angiotensin-converting enzyme inhibitors (ACE inhibitors), that include:
- Benazepril (Lotensin®), benazepril-hydrochlorothiazide (Lotensin® HCT), or benazepril-amlodipine (Lotrel®)
- Captopril (Capoten®) or captopril-hydrochlorothiazide (Capozide®)
- Enalapril (Vasotec®), enalapril-hydrochlorothiazide (Vaseretic®), or enalapril-felodipine (Lexxel®)
- Fosinopril (Monopril®) or fosinopril-hydrochlorothiazide (Monopril-HCT®)
- Lisinopril (Prinivil®, Zestril®) or lisinopril-hydrochlorothiazide (Prinzide®, Zestoretic®)
- Quinapril (Accupril®) or quinapril-hydrochlorothiazide (Accuretic®, Quinaretic®)
- Ramipril (Altace®)
- Amantadine (Symmetrel®)
- Angiotensin II receptor blockers (ARBs), comprising:
- Candesartan (Atacand®) or candesartan-hydrochlorothiazide (Atacand HCT®)
- Eposartan (Teveten®) or eposartan-hydrochlorothiazide (Teveten® HCT)
- Irbesartan (Avapro®) or irbesartan-hydrochlorothiazide (Avalide®)
- Losartan (Cozaar®) or losartan-hydrochlorothiazide (Hyzaar®)
- Olmesartan (Benicar®), olmesartan-hydrochlorothiazide (Benicar HCT®), or amlodipine and olmesartan (AZOR™)
- Telmisartan (Micardis®) or telmisartan-hydrochlorothiazide (Micardis® HCT)
- Valsartan (Diovan®) or valsartan-hydrochlorothiazide (Diovan HCT®)
- Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
- Digoxin (Digitek®, Lanoxin®)
- Dofetilide (Tikosyn®)
- Indomethacin (Indocin®)
- Leucovorin or levoleucovorin (Fusilev™)
- Methotrexate (Rheumatrex®)
- Oral diabetes medications
- Oral typhoid vaccine
- Phenytoin (Dilantin®, Phenytek®)
- Procainamide (Procanbid®)
- Pyrimethamine (Daraprim®)
- Thiazide diuretics, including:
- Chlorothiazide (Diuril®)
- Chlorthalidone (Thalitone®)
- Hydrochlorothiazide (Esidrix®, HydroDIURIL®, Microzide®, Oretic®)
- Tricyclic antidepressants, such as:
- Amitriptyline (Elavil®)
- Amoxapine (Asendin®)
- Clomipramine (Anafranil®)
- Desipramine (Norpramin®)
- Doxepin (Sinequan®)
- Imipramine (Tofranil®, Tofranil PM®)
- Maprotiline (Ludiomil®)
- Nortriptyline (Pamelor®)
- Protriptyline (Vivactil®)
- Trimipramine (Surmontil®)
- Warfarin (Coumadin®, Jantoven®).
What Medical Conditions Can Serve as a Contra-Indication to Using Bactrim?
Consult your therapist in order to get the instructions concerning the use of this drug. Inform him in case you have:
- Anemia
- Asthma
- Glucose-6-phosphate dehydrogenase deficiency
- A folic acid deficiency
- HIV or AIDS
- Porphyria
- PKU (Phenylketonuria)
- A thyroid disorder
- Kidney disorder (kidney failure, also known as renal failure)
- Liver failure (liver failure, cirrhosis, hepatitis)
- Allergies (including ones to food, dyes, preservatives).
Inform the doctor if you:
- Are pregnant or trying to become pregnant
- Are breastfeeding.
You should tell your therapist about other medications you are taking, no matter if these are prescription or non-prescription ones.
What Should I Do in Case of Overdose with Bactrim?
In case of overdose you are likely to have the following symptoms:
- Loss of appetite
- Stomach ache
- Nausea
- Vomiting
- Migraine
- Giddiness
- Drowsiness
- Unconsciousness
- Bloody urine
- Confusion
- Fever
- Jaundice
- Loss of consciousness.
Seek emergency medical care if you experience the symptoms of overdose.
What Should I Do in Case I Miss a Dose of Bactrim?
If you failed to take Bactrim in time, take it as soon as you can, unless it's time to take a new dose of the drug. In this case you should skip the one you've missed and go on taking it as scheduled. A double dose might cause overdose effects. Be careful and don't miss scheduled doses, otherwise you may develop an antibiotic-resistant infection.
Available Forms of Bactrim
The drug is available in different strengths:
- Bactrim tablets (80 mg of trimethoprim and 400 mg of sulfamethoxazole)
- Bactrim DS ("double strength") tablets (160 mg of trimethoprim and 800 mg of sulfamethoxazole).
How Should I Store Bactrim?
Bactrim should be kept at room temperature, in a dry airtight container, out of children's reach.
Is Bactrim Available in the Form of a Generic Medication?
At the moment, the drug in generic form is licensed for sale.
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