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Anafranil

Anafranil is a prescribed medication licensed to treat such anxiety-related disorders as, for instance, obsessive-compulsive disorder. Its effectiveness is explained by its ability to make certain brain chemicals rest in the tissue for a longer period of time. Anafranil, produced in the form of capsules which are usually prescribed to be taken one to three times a day, may also cause the following side effects: dizziness, drowsiness, and headaches.

What Is Anafranil And What Is It Used for?

Anafranil® (clomipramine hydrochloride) is a medication usually prescribed to adults, teens and children suffering from obsessive-compulsive disorder (OCD).

Who Manufactures Anafranil?

Generic Anafranil is produced by several different manufacturers. The brand-name version of the drug is produced by Mallinckrodt Pharmaceuticals.

In What Way Does Anafranil Work?

Anafranil is a member of the trycyclic antidepressants group. The exact mechanism of the medication's curing effect is not yet clear. It is stated that it affects a number of chemicals of the brain tissue such as serotonin and norepinephrine. It is presumed that the medication makes it possible that these chemicals stay in the brain tissue for a longer period of time, which helps with symptoms of OCD.

Even though the molecule of the medication belongs to the one of the trycyclic antidepressant type, the effect of the drug is more similar to the one of the selective serotonin reuptake inhibitors (SSRIs), the newer group of antidepressants. Anafranil is sometimes classified as one of the SSRIs also.

How Do I Take Anafranil?

The following list contains general instructions on how Anafranil should be taken if prescribed:

• Anafranil capsules are taken orally once to thrice a day.
• Anafranil intake is not food-dependant. However, it is better to be taken in the course of a meal when you have just started the treatment or are increasing the dose you take.
• Be sure you take the drug at the same time each day, so that its level in your blood is preserved equal.
• Do not violate the prescription or stop the therapy.

Anafranil Dosage

Your healthcare provider will set up the dosage for you, and that will depend on a number of factors:

• Your age
• Whether you do or do not take any other medications
• Whether you do or do not have any other health disorders.

You are not recommended to change the dosing scheme unless you're told to do so by your healthcare provider.

Possible Side Effects of Therapy with Anafranil

As any other drug, Anafranil is not free of side effects, though they do not always accompany its intake. Moreover, the majority of patients undergoing the Anafranil therapy do not encounter any problems, as even if side effects occur, they take minor forms and can be easily cured by the patient himself or with the help of his healthcare provider. Serious side effects are fewer in number and less frequently encountered. The following list shows the most common side effects of Anafranil:

• Dry mouth
• Drowsiness
• Shakiness (tremors)
• Dizziness
• Headaches
• Constipation
• Ejaculation failure.

Possible Drug Interactions with Anafranil

Anafranil® (clomipramine hydrochloride) in the course of the therapy might interact with a certain number of other medications and substances, which are as follows:

• Alcohol
• Anticholinergic medications, including:

• Atropine
• Belladonna (Donnatal®, B&O Supprettes®, Bellamine S®)
• Benztropine (Cogentin®)
• Clidinium (Librax®)
• Clozapine (Clozaril®)
• Darifenacin (Enablex®)
• Dicyclomine (Bentyl®)
• Diphenhydramine (Benadryl®, Tylenol PM®)
• Glycopyrrolate (Robinul®)
• Haloperidol (Haldol®)
• Homatropine (Hycodan®)
• Hyoscyamine (Levsin®)
• Ipratropium (Atrovent®)
• Scopolamine (Transderm Scop®)
• Tiotropium (Spiriva®)
• Tolterodine (Detrol®)
• Trospium (Sanctura®)

• Arrhythmia medications, including:

• Amiodarone (Cordarone®)
• Disopyramide (Norpace®)
• Dofetilide(Tikosyn®)
• Flecainide (Tambocor®)
• Ibutilide (Corvert®)
• Propafenone (Rythmol®)
• Quinidine
• Sotalol (Betapace®)

• Barbiturates, including:

• Amobarbital (Amytal®)
• Butalbital (Fioricet®, Fiorinal®)
• Pentobarbital (Nembutal®)
• Phenobarbital (Luminal®)
• Secobarbital (Seconal®)

• Cimetidine (Tagamet®)
• Clonidine (Catapres®)
• Digoxin (Digitek®, Lanoxin®)
• Methylphenidate (Concerta®, Daytrana®, Metadate CD®,Metadate ER®, Methylin®, Ritalin®, Ritalin LA®, Ritalin SR)
• Monoamine oxidase inhibitors (MAOIs), including:

• Isocarboxazid (Marplan®)
• Phenelzine (Nardil®)
• Rasagiline (Azilect®)
• Selegiline (Eldepryl®, Emsam®, Zelapar®)
• Tranylcypromine (Parnate®)

• Phenothiazine medications, including:

• Chlorpromazine
• Fluphenazine (Prolixin®)
• Perphenazine
• Promethazine (Phenergan®)
• Thioridazine (Mellaril®)
• Trifluoperazine

• Phenytoin (Dilantin®)
• Pressors, including:

• Dopamine (Intropin®)
• Dobutamine (Dobutrex®)
• Epinephrine (Adrenalin®, EpiPen®)
• Norepinephrine (Levophed®)

• SSRI antidepressants, including:

• Citalopram (Celexa®)
• Escitalopram (Lexapro®)
• Fluoxetine (Prozac®, Sarafem®)
• Fluvoxamine (Luvox®)
• Paroxetine (Paxil®, Paxil CR®)
• Sertraline (Zoloft®)

• Thyroid medications, including:

• Liothyronine (Cytomel®)
• Liotrix (Thyrolar®)
• Levothyroxine (Levoxyl®, Synthroid®, Unithroid®)
• Thyroid (Armour® Thyroid, Nature-Throid®)

• Other tricyclic antidepressants, including:

• Amitriptyline (Elavil®)
• Amoxapine (Asendin®)
• Desipramine (Norpramin®)
• Doxepin (Sinequan®)
• Imipramine (Tofranil®, Tofranil PM®)
• Maprotiline (Ludiomil®)
• Nortriptyline (Pamelor®)
• Protriptyline (Vivactil®)
• Trimipramine (Surmontil®)

• Warfarin (Coumadin®, Jantoven®).

What Medical Conditions Can Serve as a Contra-Indication to Using Anafranil?

You should inform your doctor if you have any conditions out of the following list:

• Bipolar disorder or a family history of bipolar disorder (also known as manic depression)
• Schizophrenia
• A history of suicide attempts or suicidal thoughts
• Severe anxiety or agitation
• A recent history of heart attack
• Heart problems, including heart disease
• Liver disease, including liver failure or cirrhosis
• Kidney problems, including kidney failure
• Hyperthyroidism (overactive thyroid)
• An adrenal tumor (such as a pheochromocytoma or neuroblastoma)
• Seizures or epilepsy
• Glaucoma
• Bladder problems or difficulty passing urine
• Any allergies, including allergies to foods, dyes, or preservatives.

Don't forget to let your doctor know if you are:

• Pregnant or planning to get pregnant in near future
• Breastfeeding a baby
• Have a surgery planned in near future
• Drink alcohol on the regular basis.

As well give him the fullest information possible on what drugs, controlled or available on free sale, vitamins, antacids, herbal food additives you take at the moment.

What Should I Do in Case of Overdose with Anafranil?

The overdose with Anafranil might have any or the combination of any of the following symptoms:

• Drowsiness
• Confusion
• Restlessness or agitation
• Severe sweating
• Muscle tension
• Unusual body movements
• A rapid heart rate (tachycardia)
• Congestive heart failure
• Irregular heart rhythms (arrhythmia)
• Cardiac arrest
• Very low blood pressure (hypotension)
• Breathing difficulty and blue skin
• Vomiting
• Fever
• Kidney problems
• Seizures
• Coma
• Death.

In case you overdose, run for immediate professional medical help.

How Should I Store Anafranil?

Anafranil should be stored in a proper airtight container at the room temperature away from humid and heated environments, and out of children's reach.

What Should I Do in Case I Miss a Dose of Anafranil?

Take your dose as soon as you remember that you've missed one, unless it is time for the next, in which case just continue according to your usual scheme. If you usually take a dose at nighttime, you are not recommended to take the missed one during the daytime as you might get drowsy under its influence. Never double a dose to make up for the one you've skipped.

What Strengths of Anafranil Are Available?

Anafranil is available for purchase in the following three strengths:

• Anafranil 25 mg
• Anafranil 50 mg
• Anafranil 75 mg.

Is Anafranil Available in the Form of a Generic Medication?

Right now Anafranil is available for purchase in the brand-name as well as in the generic forms.

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